A Flat Interface Nerve Electrode
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From computer simulations to intraoperative tests...
My current research involves developing realistic nerve models using detailed histological studies. These models are used to guide the development of neural interfaces which will ultimately restore one or more
functions in paralyzed individuals. In this very early phase, we conduct intraoperative verifcation studies on able-bodied subjects. During these studies, a surgeon places our novel electrode around a target nerve
and EMG electrodes into numerous muscles. We stimulate the nerve and determine the electrode's ability to selectively recruit different muscles. To date, we have tested electrodes on the femoral nerve in more than 10 subjects.
Results from these studies agree well with the predictions made from the computer simulations.
The computer simulations are conducted with Ansoft Maxwell 3D (finite element method (FEM) modeling), MATLAB, and NEURON. Intraoperative experiments use MATLAB, Simulink, and xPC Target software.
Hardware used during intraoperative experiments includes a "host" computer, a "target" computer, Cambridge Electronic Design (CED) and B&L Engineering amplifiers, a National Instruments (NI) data acquisition (DAQ) board,
and EMG and nerve stimulation electrodes.
Neural Imaging
In addition to the aforementioned research, I am also interested in non-invasive imaging of nerves using high-field MRI. Specifically, I would like to resolve the fine structures within the nerves that contain the axons (fascicles)
and re-construct 3D models using these images. I have not yet begun this phase of research, but I hope to within a year.
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