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case western reserve university

IRENE LEE

Department of Chemistry

 
 
Irene Lee
Associate Professor
Department of Chemistry


Office: Clapp Hall 212
Phone: 216-368-6001
Fax: 216-368-3006
E-mail: irene.lee@case.edu



Scientific Presentations


Research Posters

* Presenter

*I. Lee, D. Vineyard, J. Patterson, A. J. Berdis, "Determining the Timing of ATPase and Peptide Hydrolysis in the ATP-Dependent Protease Lon", Biopolymer Gordon Research Conference, Rohde Island , June 2004

*X. Zhang, I. Lee and A. J. Berdis, "Evaluating the Molecular Mechanism of DNA Synthesis by T4 DNA Polymerase Using Modified Indole Nucleotides as Probes", Biopolymer Gordon Research Conference, Rohde Island , June 2004

*I. Lee, J. Patterson, D. Vineyard, J. Thomas-Wohlever, R. Behshad and M. Burke, "Correlation of an Adenine-Specific Conformation with the ATP-Dependent Peptidase Activity of Escherichia coli Lon", Enzyme, Coenzyme and Metabolic Pathways, New Hampshire, July 2003

*I. Lee, J. Thomas-Wohlever and A. J. Berdis, "Elucidating the Mechanism of ATP- Dependent Peptide Hydrolysis by Escherichia coli Lon Protease", 18 th Enzyme Mechanisms Conference, Galveston Island, Texas, January 2003

*J. Thomas-Wohlever, R. Behshad, M. Burke and I. Lee, "Evaluating the Functional Consequence of Sub-optimal Nucleotide Base Interaction in the ATP-Dependent Protese Lon", 18 th Enzyme Mechanisms Conference, Galveston Island , Texas , January 2003

*I. Lee and J. Thomas-Wohlever, "Characterization of the ATP-Dependent Protease Lon by Product Inhibition Studies", Midwest Enzyme Chemistry Conference XXI, Chicago , October 2001

I. Lee and *J. Thomas-Wohlever, "Quantitative Correlation of Nucleotide Selectivity with Activation of Peptidase Activity of E. coli Lon", Midwest Enzyme Chemistry Conference XXI, Chicago , October 2001

*I. Lee and J. Thomas-Wohlever, "Kinetic Characterization of the ATP-Dependent Peptidase Mechanism of E. coli Lon", Gordon Research Conference, New Hampshire , July 2001

I. Lee and *J. Thomas-Wohlever, "Identifying the Peptide Substrate Determinants for Escherichia coli Lon Protease," Biophysical Society Meeting, Boston , February 2001

Invited Speaker at Conferences and Symposia: (1998 - present)

Frontiers in Bioorganic Chemistry, State College , PA , 1999

Invited Research Seminars: (1998 - present)

Case Western Reserve University , Department of Pharmacology 1998.

"Screening Bacteriophage Libraries for Catalytic Antibodies with Peptidase Activities".

University of Toledo , Department of Chemistry 1999.

"Understanding the Mechanism of ATP-Dependent Proteolysis".

Case Western Reserve University , Department of Biochemistry 1999.

"Understanding the Mechanism of ATP-Dependent Proteolysis".

Wayne State University , Department of Chemistry 2002.

"Examining the Molecular Basis for ATP Consumption in Energy-dependent Proteolysis"

University of Buffalo , SUNY Buffalo , Department of Chemistry 2002  

"Examining the Mechanism of ATP-Dependent Peptide Cleavage by Lon Protease"

Youngstown State University , Department of Chemistry 2002

"Examining the Mechanism of ATP-Dependent Peptide Cleavage by Lon Protease"

Westminister College , Department of Chemistry 2003

"Combating Metabolic and Infectious Diseases by Targeting Lon Protease"

University of Cincinnati , Department of Chemistry 2003

"Combating Metabolic and Infectious Diseases by Targeting Lon Protease"

Auburn University , Department of Chemistry 2004

"Mechanistic Characterization of the Stress-Induced Protease Lon"

Ohio State University , Department of Chemistry 2004

" Exploring the reaction mechanism of the ATP-dependent protease Lon"

Wesylan University , Molecular Biology and Biochemistry Department 2004

"On the mechanics of chewing up proteins by the stress-induced protease Lon"

Rutgers University , Department of Chemistry 2004

"On the Mechanics of chewing up proteins by the stress-induced protease Lon"

Prof. Lee's Research

Both protein degradation & nucleic acid metabolism are important processes in maintaining cell survival especially under stressful growth conditions. The long-term of my research is to develop ways ways to control the ... Continue

 
Teaching Philosophy

I believe the responsibility of a teacher is to provide students a safe haven to think and inspire them to take an active role in learning. My teaching strategy focuses on providing an interactive and inquiry ... Continue