Development and Implementation of Non-Natural Nucleosides and Nucleotides
DNA damaging agents represent an important component of modern chemotherapy. Unfortunately, the use of DNA damaging agents is often associated with debilitating side-effects as well as the potential for the development of therapy-related cancers that appear linked with chemotherapy. To combat these complications, our research program is developing a series of unique non-natural nucleoside analogs as adjunctive chemotherapeutic agents.
These analogs are designed to be selectively inserted opposite various pro-mutagenic DNA lesions that are caused by several chemotherapeutic DNA-damaging agents. Thus, they have the potential to behave as chemosensitizing and chemopreventive agents.
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